Weight Loss Shots in Sioux Falls, South Dakota

Where to get weight loss shots in Sioux Falls

In Sioux Falls, weight loss shots are available at local medical weight-loss clinics and med spas — ranked below by Google rating with reviews and hours — or online through licensed telehealth providers who ship semaglutide and tirzepatide to your door. Both routes require a prescription from a South Dakota-licensed clinician, who confirms your eligibility and sets your weekly dose.

Semaglutide and tirzepatide shots near Sioux Falls

The clinics listed for Sioux Falls offer once-weekly semaglutide or tirzepatide injections under physician supervision, often with in-office dosing and follow-up. If you prefer to start from home, a telehealth provider can prescribe compounded shots and deliver them to Sioux Falls within a few days. Compare local clinics and online delivery to find what fits your schedule and budget.

What weight loss shots cost in Sioux Falls

In Sioux Falls, brand-name shots (Wegovy, Zepbound) cost roughly $1,000–$1,400/month without insurance, while compounded semaglutide or tirzepatide through telehealth starts around $199/month all-inclusive. If your South Dakota plan covers a GLP-1, your copay may drop to $25–$50. Many local clinics offer monthly membership pricing — check the listings below and compare against online options.

Semaglutide vs. tirzepatide & the GLP-1 options

Brand-name and compounded options available to Sioux Falls patients

Shot	Molecule	Approved for	Frequency	Typical price
Ozempic	Semaglutide	Type 2 diabetes (off-label weight loss)	Once weekly	$950–$1,350/mo
Wegovy	Semaglutide	Chronic weight management	Once weekly	$1,300–$1,400/mo
Mounjaro	Tirzepatide	Type 2 diabetes (off-label weight loss)	Once weekly	$1,000–$1,200/mo
Zepbound	Tirzepatide	Chronic weight management	Once weekly	$1,000–$1,060/mo
Compounded	Semaglutide / Tirzepatide	Cash-pay telehealth option	Once weekly	$199–$499/mo

Prices are typical U.S. cash-pay ranges without insurance; manufacturer savings cards and coverage can lower brand-name costs significantly.

Three ways to get weight loss shots in Sioux Falls

Compare by speed, price and how you prefer to be seen

Telehealth delivery

From $199/mo (compounded)

Online consultation with a licensed provider, medication shipped to your door. Fastest cash-pay route, no insurance needed.

Best for speed & convenience

Find Weight Loss Shots

Local clinics & med spas

Varies by clinic

In-person medical weight loss clinics near you — physician oversight, injections on site, personalized follow-up.

Best for in-person care

See clinics below

Retail pharmacy + insurance

Copay $25–$50 if covered

Brand-name Ozempic/Wegovy/Mounjaro/Zepbound with a prescription, filled at your pharmacy. Cheapest if covered.

Best if you have coverage

Learn more

Weight loss clinics in Sioux Falls, SD

12 clinics offering GLP-1 treatment near Sioux Falls, ranked by Google rating

Sioux Falls Secret for Weight Loss

4.9 (35 reviews) Weight loss service Today: Closed

600 W 37th St Suite A, Sioux Falls, SD 57105

(605) 274-6262

“You guys are very friendly, encouraging, and flexible. I have learned a lot and am eager to continue losing weight at this pace. I feel good every day and I …” — Sue Wagner

Yevo Semaglutide & Weight Loss of Sioux Falls

Weight loss service Today: Open 24 hours

2841 E Old Orchard Trail, Sioux Falls, SD 57103

(951) 507-1118

Sioux Falls Hypnosis

4.9 (150 reviews) Hypnotherapy service Today: Closed

Regus Office Center, 101 S Reid St Suite 307 (3rd Floor, Sioux Falls, SD 57103

(605) 702-6691

“O finally have quit smoking thanks to hypnosis. After many years and tries. I have conquered the monkey on my back. Try it to help you” — Debra Voigt

Sanford Weight Management Center

5.0 Nutritionist Today: Closed

3401 W 49th St, Sioux Falls, SD 57106

(605) 328-8670

“Dr. Jennifer Schriever and Lindsay Stern are some of the best people I’ve ever witnessed in healthcare… And this is come coming from someone who spent almost a…” — Jess Schnyders

iv&co.

5.0 Medical spa Today: 9 AM–3 PM

345 S Reid St STE. 123, Sioux Falls, SD 57103

(605) 271-0715

“Relaxing, knowledgeable staff, calming environment! Always a positive experience when I go!” — Jerrica C

Avera Comprehensive Weight Management — 41st & Holbrook

2.7 (10 reviews) Weight loss service Today: Closed

6000 W 41st St Ste 100, Sioux Falls, SD 57106

(605) 504-0400

“The late, missed appointment policy is outrageous. Receptionists are extremely rude and unprofessional. If I could give zero stars I would.” — Samantha Kastengren

Liv Med Spa | Sioux Falls, SD

5.0 Medical spa Today: 10 AM–2 PM

2500 S Lorraine Pl #1, Sioux Falls, SD 57106

(605) 681-6228

“I received the Radiesse treatment at Liv this week. I had an incredible experience. The staff were very thorough in explaining the pros/cons, risks, and afterc…” — brooke goodale

LaVie Ideal Protein Virtual Clinic

4.9 (12 reviews) Weight loss service

2310 S Marion Rd Unit 160, Sioux Falls, SD 57106

(605) 201-0282

“Wendy at Weigh 2 Go is phenomenal! So many times I have wanted to quit and she has turned my attitude around. I have lost almost 80 pounds with Wendy and I a…” — Nancy Dickmann

Encompass Wellness & Aesthetics

4.9 Weight loss service Today: Closed

4301 W 57th St #160, Sioux Falls, SD 57108

(605) 740-0414

“Love this place! Everyone is so welcoming and kind! 10/10 recommend” — Maycee Guyer

#10

Gameday Men's Health Sioux Falls, SD

5.0 (138 reviews) Weight loss service Today: Closed

4908 E Rosa Parks Pl, Sioux Falls, SD 57110

(605) 600-5454

“Staff was pleasant. Clean, organized and overall Great atmosphere. Labs were quick and the whole process was generally easy.” — michael gabriel

#11

Sanford Imagenetics

4.1 Medical Center Today: Closed

1321 W 22nd St, Sioux Falls, SD 57105

(605) 404-4000

“Great staff, specifically the lady who just attended to me at the front desk, she is so kind and has a big bright smile…. I didn’t catch her name. I have been …” — NJERI KIMEMIA

#12

The Retreat at Cedar Creek - Sioux Falls Weight Loss, Red Light Body Contouring & Wellness Center

5.0 Wellness center Today: Closed

5032 S Bur Oak Pl #110, Sioux Falls, SD 57108

(605) 789-7767

“Amber did a great job of explaining everything you are doing. Found the experience great! Hard to tell benefits only after two days and one treatment,” — Tami Curtis

Prefer to start from home? A licensed provider can prescribe and ship your GLP-1 to Sioux Falls in a few days.

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What to expect: dosing & side effects

GLP-1 medications are given as a once-weekly subcutaneous injection, starting at a low dose that your provider increases gradually over several weeks to limit side effects. Most Sioux Falls patients self-inject at home after a short demonstration.

The most common side effects are nausea, diarrhea, constipation, decreased appetite and mild injection-site reactions — usually mild and fading over the first few weeks. Rare but serious risks include pancreatitis, gallbladder issues and thyroid concerns; GLP-1s should not be used by people with a personal or family history of medullary thyroid carcinoma or MEN 2. Your provider reviews your full history before prescribing.

Ways to save in Sioux Falls

Coverage and cash-pay options

Insurance Coverage

Many commercial plans cover GLP-1 therapy for eligible patients. Your provider can submit prior authorization for brand-name options.

Copay as low as $25–$50/month with insurance

HSA / FSA Eligible

GLP-1 medication prescribed by a licensed provider is an eligible HSA/FSA expense.

Pay with pre-tax dollars, saving 20–35%

Manufacturer Savings

Novo Nordisk and Eli Lilly offer savings cards for commercially insured patients who meet eligibility requirements.

Save up to $500+/month on eligible brands

Cash-Pay Compounded

Compounded semaglutide/tirzepatide via telehealth offers the lowest cash-pay entry point with no insurance.

All-inclusive plans from $199/month

Frequently asked questions

GLP-1 treatment in Sioux Falls, South Dakota

Semaglutide (Ozempic, Wegovy) targets one receptor and averages ~15% weight loss; tirzepatide (Mounjaro, Zepbound) targets two receptors and reaches up to ~22.5%. Tirzepatide is generally more effective but costs more. A Sioux Falls provider helps you choose.

Not much. The shots use a short, thin needle (4–5 mm) injected just under the skin, and most patients describe it as a quick pinch. Your Sioux Falls provider or clinic will show you how to self-inject, rotating between the abdomen, thigh and upper arm.

No. Sioux Falls telehealth providers offer cash-pay compounded options with a free online consultation, and HSA/FSA cards are accepted. Insurance is applied when available to further reduce your cost.

Coverage varies widely by plan in South Dakota. Many commercial plans cover Mounjaro for diabetes and Wegovy/Zepbound for weight management with prior authorization. Medicare Part D may cover diabetes indications but generally not weight-loss use. A Sioux Falls provider can verify benefits and file prior authorization.

Both are tirzepatide from Eli Lilly. Mounjaro is approved for type 2 diabetes, Zepbound for chronic weight management. The molecule and weekly dosing are identical — only the indication differs.

Some weight regain is common after stopping, with patients often regaining a portion within a year. Providers usually recommend gradual tapering and building sustainable habits while on the medication. Your Sioux Falls provider can design a long-term or maintenance plan.

Weight Loss Shots in Sioux Falls, South Dakota

Where to get weight loss shots in Sioux Falls

Semaglutide and tirzepatide shots near Sioux Falls

What weight loss shots cost in Sioux Falls

How to get weight loss shots in Sioux Falls

Check your eligibility

Get your prescription

Start weekly treatment

Am I eligible for a GLP-1 in Sioux Falls?

Semaglutide vs. tirzepatide & the GLP-1 options